The subtle effects of an SSRI


One of the things that has puzzled me as my dose of Paxil has gotten lower is the way that old friends marvel at all the changes they see in me.  Even causal, but long time, acquaintances say that I seem like a completely different person.  They’re even people who I haven’t told about my Paxil tapering.  Somehow, I’ve transformed in front of their eyes over the past year.  I haven’t questioned them too closely about how I’ve changed, even though I’m very curious.  To me, I seem exactly the same.  I’ve always been “me”, haven’t I? I keep looking for specific things that I do differently, but they seem like little things.  I don’t interrupt other people’s conversations to say something that just popped into my head anymore.  I think that’s different.  Still, that seems like a small personality change, not something that people would notice immediately.

That changed a bit yesterday.  I had a difficult day at work.  I was configuring two routers in our network to talk to each other for a customer.  The interfaces weren’t built, the NNI was designed on the wrong router, I had to redistribute MPLS routes across two different sections of our edge network.  Suffice to say, it got complicated.  And, it lasted for 14 hours.  By the time I got home, I had only eaten a few candy bars in the previous 36 hours and I was dead tired.  I stuffed a couple cheese sandwiches in my mouth and went to bed.  I had to be back at work 7 hours later.

This morning, I woke up tired and grumpy.  I had a bit of a persecution complex as I showered and watched the DVR from last night.  I shuffled into work and started getting ready for the day.  A friend of mine asked if I was going slomo today.  Everyone else noticed the difference, too.  “Are you ok?” “How late did you stay last night? I left at 10 and you were still here.”

I realized that I was feeling the same way I had felt every day while I was on 40mg/day of Paxil.  I never seemed to get enough sleep, and I was always irritated.  There were long stretches where I would sleep for 12-14 hours a night, and still wake up exhausted.  Every little thing annoyed me.  I didn’t contribute at work, I just went through the motions.  The difference today was that irritated feeling faded away like it would for a normal person.  By the end of the day, I was joking and helping my next door neighbor with a config.  In my Paxil days it would have lingered all day, and I would have gone home much as I had left it, irritated and tired.

I didn’t think yesterday was a good day.  Looking back, it was pretty good.  I got the customer working eventually, and I learned something about the ways that I’ve changed since I started tapering off Paxil.  It turns out, Paxil made me feel like I was working on an intractable problem for 16 hours a day, every day.

29 Responses to “The subtle effects of an SSRI”

  1. jms40plus Says:

    The biggest change for me is lack of interest in alcohol. I was out of control and drinking every time I felt ‘high’ now I dont have those ‘high’ feelings anymore . Its a most dramatic change actually. Now I get happily bored and feel so much calmer. Its strange how you remember the Paxil days, to me its like one long nightmare where I wasnt myself at all lost friends and got into loads of trouble !! So glad I managed to suffer the withdrawal within an inch of my life long enough to be almost prescription free .

    • npanth Says:

      I was starting to drink a lot towards the end of my time on Paxil. Looking back, I can see that it was going to get out of hand. A lot of people report that they started drinking, drugs, gambling on SSRI. It’s a weird side effect.
      Like you, it just kind of faded away when I started tapering.

      • Hope Says:

        Dear James,

        I’m one of the victims from ssri withdrawal. I have read tons of posts online and found all from you are the most instructive and solid with understanding

        I am glad I eventually found this blog of yours tracing from various forums where I saw your posts initially.

        It seems all those forums are closed back last year or earlier. I sincerely hope you get this one note.

        I hope I can get in touch with you in some forms appropriate.

        Warmest regards,

    • Mags Says:

      Dear James, I am trying to figure out this word press thing. I can’t tell you how grateful I am to find your blogs and information here. I have not been able to find ANYTHING on the internet is this informative. I am trying so very hard to not lose hope that I will always feel this bad. I keep contemplating going back on the Paxil. Someone please, please tell me that it gets better.

  2. Christoffer Says:

    You are a life saver.
    Thank you so much for all the posts on SSRI withdrawal.
    Please keep writing.
    I read every day to help myself through this.

    • Plog Poster Says:

      Dear Christoffer — How is it going with your withdrawal? I am suffering with it too. Sometimes it feels overwhelming. I’m not sure James is still interacting with his blog. I need some support and have found helpful post on this site. Yet I still feel very overwhelmed and alone in this process. Would love to hear from you.

  3. Lilu Says:

    How did you realize that the repetitive thoughts are part of withdrawal? I have been tapering Lexapro for the last 5 months, and have noticed that as well. I don’t have a repeating thought for 4 hours, but I have noticed that after every interaction, every conversation, the things I said will keep repeating in my mind over and over, like instant replay. As if I am reviewing and scrutinizing the things that I said, and evaluating my words over and over again.

    • Plog Poster Says:

      I have been off Celexa (citalopram) since Mar 12, 2014 after a six-month taper (having been on antidepressants for 11 years) and continue to struggle with anguish and fear. Can any one help me get a sense about how long this kind interior torment persists? There are people (family) in my life who do not understand my need to have gone on medication in the first place and don’t have any idea how difficult it is to “go off” medication. Sometimes when it gets really bad, I think I need to go back on. Then I feel defeated and full of despair, including all associated thoughts. Can any one give me hope?

  4. PC Says:

    Cannot thank you enough for all the thought and honesty and care and intelligence you put into writing about your SSRI withdrawal symptoms. Scrolling through has been a big help and your writing will help me a lot as I move forward through my own withdrawal. All the very best to you.

  5. Plog Poster Says:

    I have been reading your postings about SSRI withdrawal and have found them grounding and helpful. I am wondering how you are doing (I write this in April 2014; most posts seem to date over a year ago). I have made the decision to go off my medication after 10 years and I am finding the withdrawal alarming. I feel the need to confer with someone who has been down this road and somehow made it through. Right now, I am struggling far beyond anything I experienced with my “general depression.” In fact, I fear I am damaging relationships because of my intensity. Are you still interacting with people about this? If so, I would like to hear from you. I truly need help.

    • Lilu Says:

      DO NOT…I repeat Do Not quit any psych drug, cold-turkey. Especially after being on one longer than a year. You have to taper, very very slowly. For some of us, it means switching to a liquid version of a medication or compatible one that is available in liquid, and tapering as slow as 5% per week or month. There are physical changes that take place in the brain after using antidepressants. For more info and support, see

      • Plog Poster Says:

        Thanks, Lily — For whatever it is worth, I have been tapering for months, since October `13. I stopped altogether after I had gotten down to 5mg from 40 over 5 months. Even so, I am experiencing emotional disequilibrium unlike anything I experienced before I went on medication.

        • Plog Poster Says:

          Sorry — I mean *Lilu*

          • Lilu Says:

            5 mg is still too high to quit cold turkey. You have to go slow as to NOT have symptoms or hardly have symptoms at all. I was tapering at 10% a week using liquid lexapro, and had to go down to 5% a week. If the symptoms are too severe, then you have hold the dose until they subside. I am down to 0.8mg. And recently I was shocked to see that I started experiencing side effects when my pharmacy (without telling me) switched the manufacturer of my generic liquid escitalopram! That is how sensitive to meds I’ve become. It’s insane. Recently I have started taking supplements that work much like antidepressants, and they are finally helping. Being on such a low dose of an antidepressant, there is no risk of serotonin syndrome or other unpleasant side effects. Based on Marty Heinz research, I am taking a combination of 5-htp 100 mg (at night) and L-tyrosine 750 mg in the morning. Both have to be taken on an empty stomach and not with a liquid that has protein in it, like milk or a milk shake. I also take P-5-P, which is a coenzymated version of vitamin B6 and is an activator for these amino acids. One can also add SAMe in the morning for extra energy and drive. This is the first time I am seeing these supplements take the edge off my withdrawal, which was leaving me angry, irritable, and tired all the time. I will also be experimenting with increasing the dose of each supplement or adding other supplements which help with mood, such as magnesium, inositol, and omega-3s.

  6. Plog Poster Says:

    Thank you for responding Lilu, I feel a little confused about your tapering regimen — it sounds kind of complicated. I’ll study it a little more when I have time (not today). Do the withdrawal symptoms ever settle out, in spite of the fact of having made the mistake of not tapering slowly enough?

    • Lilu Says:

      I am tapering as advised by the website. You will find lots of help, instructions, and support there. No one person’s experience is indicative of what yours will be like. We all have a somewhat different bio-chemistry.

      • Plog Poster Says:

        Thanks so much for this. I hope things go well for you.

      • Plog Poster Says:

        Dear Lilu,
        I reached a very difficult breaking point today and have reinstated. My doctor put me back on 20mg of citalopram. I questioned her about going back to that dosage after I had tapered so excruciatingly over many months. She said I needed to get as much back in to my system as quickly as possible. I have surrendered my process into her hands because she is a good doctor and I trust her. I also had to take into consideration the people in my life who are adversely affected by my symptoms.

        I feel very broken. I just want my life back. It has been an excruciating ordeal. It has caused damage in some relationships. I don’t know what the answer is. I only know I reached a point of almost nonfunctionability and hopelessness.

        What are your thoughts on this?

        • Lilu Says:

          Hi Plog,
          I do have a lot to say about this. All Psychiatrists, including mine, who is also the nicest one I’ve ever met, will want to put you back on meds when you are having a hard time. I believe this is a mistake. I think it’s especially bad to put you back on a much higher dose than where you were at. If you quit cold turkey after getting down to 5 mg, then this is the dose you need to reinstate. I hope you haven’t taken the 20 mg for long. I advise you to just take just 5 mg, or 10 mg at most. Not 20. Tapering up is just as important as tapering down. Stay on that dose for a month until you stabilize. Then you can ask your doctor to prescribe you liquid medication and taper at 5% to 10% per week, every two weeks, or once a month, depending. If Celexa doesn’t come in a liquid, then switch to Lexapro, which is twice as strong. So, 10 mg of Citalopram is equivalent to 5 mg of Escitalopram. That’s what I did. I was actually on Pristiq 50 mg, which started making my physical and emotional state really bad. As soon as I switched to Lexapro 5 mg, I got better.
          Now, in terms of going through a rough patch. The only way out is through. Back in January, I had a relapse, and sacrificed months of tapering and getting down to 1 mg, by going back up to 2 mg. After stabilizing, I re-started my taper. And what happened, as soon as I crossed the 1 mg threshold, my withdrawal intensified. Constant anger, irritability, depressed mood, short temper, etc. BUT…this time, I decided that I was going to stick to the taper, and just ride it out. And I’m glad I did, cause now I’m feeling better. It took over a month, and I went from 1 mg to .7 mg, but I survived without reinstating. It seems that what they describe on is true about the waves and windows of withdrawal. Waves are when you are crashing, and windows are when you feel good. I really encourage you to join, and post, and get support there. Really. I’m on there as Lilu as well.
          My doctor has also recommended that I take Omega-3 supplements to help with the withdrawal symptoms. She uses Nordic Naturals brand, 1-2 gms, 2:3 ratio of dha to epa. I’m going to get these tomorrow, and see if they help. An unfortunate side effect of antidepressant withdrawal for many people is that even a calm laid back person can start experiencing blind uncontrollable rage. Ughhhhh….. so sad.
          Please let’s continue this conversation on Create an account, then go to Introductions and start a topic. If you you use the same nic plog poster, i’ll look for you. Ok?

          • Plog Poster Says:

            Lilu, Thank you for your prompt reply. I have taken the first reinstatement dose of 20mg. I hesitated but then felt I had to trust my doctor. Having taken only one dose today, is it problematic to cut that back for the second dose tomorrow? This is all so overwhelming. I don’t know what to believe and what to do. All I know is that my life has been falling apart, day-by-day, as the discontinuation has gone on and it’s taking a toll on everyone in my life. What is the point of being off meds if my life is a wreck and I’m in despair?

            I’ll think about the website interaction. Everything is really tough for me right now. I am barely functioning and I have to support myself (I am divorced with no support from my ex-husband). Please let me know your thoughts about the fact I have taken my first dose at 20 mg. Is it too late to cut it back? I am so confused and broken. Thanks for your help.

          • Lilu Says:

            Hi Plog, hang in there. Since you only took one pill, it would be ok to just half of that. If you are able to interact on this website, you’ll have no problem with the other website either. Just put in a username, password, and email, and you will have LOTS of people giving you advice and support. You could tell us your whole story there, and we’ll be able to advise you much better. Really. This is not the right website for us to be corresponding about this. Common Plog Poster, you can do it. The question that you pose is a good one, and we all wonder about it, and I would have to know more about how you wound up on antidepressants and why. But please, I don’t want to keep corresponding on this site. Ok? You need to hear from many different people, and reading about their experiences will help you as well. In the meantime, if you are in distress right now, do something to make yourself feel better, by focusing on the present moment, closing your eyes, taking slow deep breaths and practicing just watching your thoughts go by. You could also take a bubble bath, and again, focus on the five senses and what they are perceiving in the present moment. I also find it that taking walks in nature, taking photographs of flowers closeup, is very therapeutic. Listening to new age music, stretching on the floor, or watching something funny on tv – these all help when I’m feeling really down or upset. I’ve been where you are, and you need to know that this too shall pass. Ok, I’m getting off the computer now, but I really hope you go and sign up at the site i mentioned when you are feeling better.

          • Lilu Says:

            PS The most therapeutic thing you could do when you are very upset, is to write in a journal. Just write how you are feeling, write anything that comes, get it out on paper, out of your head. I’ve been doing just that for years. It’s better than seeing a therapist. Also, write down, right now, all the things you are grateful for. Even if you don’t think there is anything. Even if you don’t feel like it. Gratitude really creates a shift in perception. Also observe and write down your negative thoughts, beliefs,ideas. Challenge them as not being absolute truth. Recognize that they are just ideas that your mind makes up. Recognize that they are NOT the truth. Recognize that they are NOT YOU.

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  8. Lynette Piercey Says:

    Thank you for this. I was on Paxil for 10 years. I went on it after I had a panic attack due to menopause and ended up in the hospital thinking I was having a heart attack. A nurse on duty told me that I should try it as she was on it and it was fabulous and non addictive. So that started the biggest mistake of my life. When I finally did decide to go of of it my doctor took me off in three weeks. By then I was on 30mgs. I didn’t know anything about tapering or how horrible my life was going to spiral out of control. It has been 2years now and one other ssri later to stop the horrendous withdrawals. All I got from my then doctor was oh sorry about that. Guess I should have researched it better. Needless to say I no longer see this doctor for anything to do with ssri’s. Today is my first day of being drug free after a very Dow taper I am holding my breath as I know withdrawal will come, but I hope not as severe as I have experienced. Ten years ago I was also put on lorazapam for insomnia which was also given to me for 10 years. I have been free of that for four months now and am getting windows and waves. My life vest window being 6days opposed by a four day wave. I am into my fourth day of a wave again and today is not as bad as yesterday. I really wish the medical society would research these medications more tthoroughly before dishing them out and telling patients they aren’t addictive and are easy to quit. They are causing so much pain. Thank you again and it was nice to finally vent to someone as I have no family or friend support anymore. They don’tt understand and I guess that is normal.

    • Michael Harper Says:

      How are you doing now Lynette? I’m two months fast taper off of paxil / seroxat and really suffering – I’m trying pregabalin (non ssri) to see if it can help with the symptoms.

  9. Gina Seward Says:

    You have literally saved my life! I have been dealing with the symptoms of SSRI withdrawal for the last 3 weeks. Someone recommend that I read your information! Today I was completely suicidal! I spent the morning planning. Then I began perusing the internet and somehow ended up at your site! I cried, I laughed, and I yelled! The information you have provided was truly life saving! It gave me hope and allowed me to realize that this will end eventually! Whew! It has been touch and go! Thank you from the bottom of my heart!!! My husband thanks you as well!

  10. Dreana Rizzo Says:

    Are you still on this site?

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